Preclinical Alzheimer’s Disease accurate prediction using plasma cell‐free RNA sequences

CentroidHomfold-LAST: accurate prediction of RNA secondary structure using automatically collected homologous sequences

Although secondary structure predictions of an individual RNA sequence have been widely used in a number of sequence analyses of RNAs, accuracy is still limited. Recently, we proposed a method (called 'CentroidHomfold'), which includes information about homologous sequences into the prediction of the secondary structure of the target sequence, and showed that it substantially improved the perfo...

Cognitive Impairments in Siblings of Alzheimers Disease Patients: Possible Preclinical Signs of the Disease

Prediction of RNA Secondary Structure from Random Sequences Using ZEM

ISSN 2277 – 5048 | © 2012 Bonfring Abstract--The biological role of many RNA crucially depends on their structure. The in depth understanding of the secondary structure of RNA would provide a better insight in to their functionality. Predicting secondary structure of RNA is the most important factor in determining its 3D structure and functions. This work proposes a model for exploring the feat...

RactIP: fast and accurate prediction of RNA-RNA interaction using integer programming

MOTIVATION Considerable attention has been focused on predicting RNA-RNA interaction since it is a key to identifying possible targets of non-coding small RNAs that regulate gene expression post-transcriptionally. A number of computational studies have so far been devoted to predicting joint secondary structures or binding sites under a specific class of interactions. In general, there is a tra...

Secondary structure prediction for aligned RNA sequences.

Most functional RNA molecules have characteristic secondary structures that are highly conserved in evolution. Here we present a method for computing the consensus structure of a set aligned RNA sequences taking into account both thermodynamic stability and sequence covariation. Comparison with phylogenetic structures of rRNAs shows that a reliability of prediction of more than 80% is achieved ...